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Magic™ Antibody Discovery - Human Neprilysin / MME / CD10 (52-750) Membrane Protein, Partial, hIgG1 Fc- tag (CAT#: MP0701F)

Datasheet
This membrane protein is Human Neprilysin / MME / CD10 (52-750). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Neprilysin / MME / CD10
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 106.8 kDa. The protein migrates as 106-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Tyr 52 - Trp 750 (Accession # NP_000893.2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Neprilysin / MME / CD10
  • Full Name
  • membrane metalloendopeptidase
  • Introduction
  • The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
  • Alternative Names
  • NEP; SFE; CD10; CALLA; CMT2T; SCA43; neprilysin; atriopeptidase; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; skin fibroblast elastase

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