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Magic™ Antibody Discovery - Human RANK / TNFRSF11A (30-212) Membrane Protein, Partial, -mIgG2a Fc tag, low endotoxin (CAT#: MP0830F)

Datasheet
This membrane protein is Human RANK / TNFRSF11A (21-263). It has been tested in SDS-PAGE, ELISA, SPR, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RANK / TNFRSF11A
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 47.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ile 30 - Pro 212 (Accession # Q9Y6Q6-1)

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SPR, BLI
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG2a Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • RANK / TNFRSF11A
  • Full Name
  • TNF receptor superfamily member 11a
  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
  • Alternative Names
  • FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; tumor necrosis factor receptor superfamily member 11A; Paget disease of bone 2; loss of heterozygosity, 18, chromosomal region 1; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

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