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Magic™ Antibody Discovery - Human RNF43 (44-197) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0837F)

Datasheet
This membrane protein is Human RNF43 (22-146). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RNF43
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 43.5 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 44 - Tyr 197 (Accession # Q68DV7-1)

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Please contact us for detailed information.

Target

  • Target Protein
  • RNF43
  • Full Name
  • ring finger protein 43
  • Introduction
  • The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • URCC; SSPCS; RNF124; E3 ubiquitin-protein ligase RNF43; RING-type E3 ubiquitin transferase RNF43

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