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Magic™ Antibody Discovery - Human TFPI (29-282) Membrane Protein, Partial, -His tag (CAT#: MP0434F)

Datasheet
This membrane protein is Human TFPI (29-282). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TFPI
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 30.0 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Asp 29 - Lys 282 (Accession # NP_006278.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TFPI
  • Full Name
  • tissue factor pathway inhibitor
  • Introduction
  • This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
  • Alternative Names
  • EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

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