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Magic™ Antibody Discovery - Human TGF-beta RII / TGFBR2 (23-159) Membrane Protein, Partial, -hIgG1 Fc -Avi tag, [Biotin] (CAT#: MP0438F)

Datasheet
This membrane protein is Human TGF-beta RII / TGFBR2 (23-159). It has been tested in SDS-PAGE, ELISA, SEC-MALS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TGF-beta RII / TGFBR2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 43.7 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Thr 23 - Asp 159 (Accession # P37173-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-MALS
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus, followed by a Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TGF-beta RII / TGFBR2
  • Full Name
  • transforming growth factor beta receptor 2
  • Introduction
  • The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
  • Alternative Names
  • AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; TGF-beta receptor type IIB; TGF-beta type II receptor; tbetaR-II; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma

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