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Magic™ Antibody Discovery - Human Tyk2 (575-869) Membrane Protein, Partial, His- tag (CAT#: MP0467F)

Datasheet
This membrane protein is Human Tyk2 (575-869). It has been tested in SDS-PAGE, SEC-MALS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Tyk2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 35.0 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Asn 575 - Leu 869 (Accession # P29597-1).

Product Description

  • Application
  • SDS-PAGE, SEC-MALS
  • Expression Systems
  • Baculovirus-Insect cells
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM HEPES, 500 mM NaCl, 2 mM TCEP, pH7.5 with glycerol as protectant.

Target

  • Target Protein
  • Tyk2
  • Full Name
  • tyrosine kinase 2
  • Introduction
  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
  • Alternative Names
  • JTK1; IMD35; non-receptor tyrosine-protein kinase TYK2

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