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Magic™ Antibody Discovery - Mouse Flt-3 / Flk-2 (28-544) Membrane Protein, Partial, -His tag (CAT#: MP0121F)

Datasheet
This membrane protein is Mouse Flt-3 / Flk-2 (28-544). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • Flt-3 / Flk-2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Asn 28 - Ser 544 (Accession # NP_034359.2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Flt-3 / Flk-2
  • Full Name
  • FMS-like tyrosine kinase 3
  • Introduction
  • This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
  • Alternative Names
  • Flk; wmf; Flk-; Flk2; Flt-; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; fetal liver kinase 2; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2

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