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Magic™ Antibody Discovery - Mouse VEGFR1 / Flt-1 (23-759) Membrane Protein, Partial, -mIgG2a Fc tag, low endotoxin (CAT#: MP0549F)

Datasheet
This membrane protein is Mouse VEGFR1 / Flt-1 (23-759). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • VEGFR1 / Flt-1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 109.8 kDa. The protein migrates as 140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Tyr 23 - Glu 759 (Accession # P35969-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG2a Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • VEGFR1 / Flt-1
  • Full Name
  • FMS-like tyrosine kinase 1
  • Introduction
  • This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
  • Alternative Names
  • sFl; Flt-; VEGF; Flt-1; VEGFR; sFlt1; VEGFR1; VEGFR-1; AI323757; vascular endothelial growth factor receptor 1; embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor

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