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Magic™ Antibody Discovery - Rat IL-2 R beta&IL-2 R alpha&IL-2 R gamma (27-239(IL-2RB)&22-235 (IL-2RA)&25-262(IL-2RG)) Membrane Protein, Partial (CAT#: MPX4729K)

Datasheet
This membrane protein is Rat IL-2 R beta&IL-2 R alpha&IL-2 R gamma. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Rat
  • Target Protein
  • IL-2 R beta&IL-2 R alpha&IL-2 R gamma
  • Protein Length
  • ECD
  • Protein Class
  • Receptor
  • Molecular Weight
  • 30.2 kDa (IL-2RB) and 59.3 kDa (IL-2RA&IL-2RG)
  • TMD
  • 1
  • Sequence
  • AA Ala 27 - Glu 239 (IL-2RB) & Glu 22 - Gln 235 (IL-2RA) & Ser 25 - Ala 262 (IL-2RG) (Accession # P26896-1(IL-2RB) & P26897-1(IL-2RA) & Q68FU6-1(IL-2RG))

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • Subunit IL-2RB is fused with a his tag at the C-terminus and subunit IL-2RA&IL-2RG is fused with a StrepII Tag at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU per μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4

Target

  • Target Protein
  • IL-2 R beta&IL-2 R alpha&IL-2 R gamma
  • Full Name
  • Interleukin 2 receptor subunit beta & Interleukin 2 receptor subunit alpha & Interleukin 2 receptor subunit gamma
  • Introduction
  • Enables interleukin-2 binding activity and interleukin-2 receptor activity. Involved in cytokine-mediated signaling pathway and natural killer cell activation. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta).
    Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha).
    Predicted to enable interleukin-15 receptor activity and interleukin-2 binding activity. Predicted to be involved in interleukin-15-mediated signaling pathway and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
  • Alternative Names
  • IL-2 R beta&IL-2 R alpha&IL-2 R gamma; IL-2RB&IL-2RA&IL-2RG

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