Q&As
What accounts for the ability of EspH to regulate the actin cytoskeleton?
Related studies suggest that this may be due to its ability to bind and inhibit the Dbl homology-prenyl homology (DH-PH) structural domain of Rho guanine nucleotide exchange factors (RhoGEFs). Other effects attributed to EspH include focal adhesion disassembly to trigger host detachment and activation of cysteinase-3 to promote host cytotoxicity and death.
2022-12-21
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