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Magic™ Membrane Protein Hepatitis C virus E1 glycoprotein (HCV E1 glycoprotein) (CAT#: MP0012F)

Datasheet
The hepatitis C virus (HCV) envelop proteins E1 and E2 play a key role in host cell entry and represent important targets for vaccine and drug development.

Product Specifications

  • Host Species
  • Hepatitis C virus
  • Target Protein
  • E1 glycoprotein
  • Protein Length
  • Full Length
  • Protein Class
  • Envelop protein
  • Molecular Weight
  • 21 kDa
  • TMD
  • 1

Product Description

  • Activity
  • Validated
  • Application
  • Screening & display technologies, vaccine development
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein and Strep tag fused to the C-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >60% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • E1 glycoprotein
  • Full Name
  • HCV E1 glycoprotein
  • Introduction
  • E1 is one of two subunits of the envelope glycoprotein found in the hepatitis C virus. The other subunit is E2. This protein is a type 1 transmembrane protein with a highly glycosylated N-terminal ectodomain and a C-terminal hydrophobic anchor. After being synthesized the E1 glycoproteins associates with the E2 glycoprotein as a noncovalent heterodimer.
  • Alternative Names
  • HCV envelop protein 1, E1

Customer reviews and Q&As    

Q&As

What are the two regions of the E1 glycoprotein targeted by neutralizing antibodies?

Residues 192-202 and residues 313-324. Residues 192-202 (numbering according to the sequence of the prototype H77 strain) are recognized by the weakly neutralizing antibody H-111 and the cross-reactive nAbs IGH-526 and IGH-505 recognize residues 313-324.
2022-12-19

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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