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Magic™ Membrane Protein Human ADGRE5 (Adhesion G protein-coupled receptor E5) Expressed in CHO for Antibody Discovery, Partial (21-398aa) (CAT#: MPX0174K)

Datasheet
This product is a 42 kDa Human ADGRE5 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADGRE5
  • Protein Length
  • Partial (21-398aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 42 kDa
  • TMD
  • 7
  • Sequence
  • QDSRGCARWCPQNSSCVNATACRCNPGFSS
    FSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPV
    SGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKF
    IPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPN
    GPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNN
    QKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN
    VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPF
    TYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAV

Product Description

  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

  • Target Protein
  • ADGRE5
  • Full Name
  • Adhesion G protein-coupled receptor E5
  • Introduction
  • This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
  • Alternative Names
  • ADGRE5; CD97; TM7LN1; CD97 molecule; leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation; Adhesion G protein-coupled receptor E5

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