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Magic™ Membrane Protein Human AGRN (Agrin) Expressed in CHO for Antibody Discovery, Partial (1260-2045aa) (CAT#: MPX0135K)

Datasheet
This product is a 83.5 kDa Human AGRN membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • AGRN
  • Protein Length
  • Partial (1260-2045aa)
  • Protein Class
  • Transporter
  • Molecular Weight
  • 83.5 kDa
  • Sequence
  • ATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAK
    TTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALG
    GGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEF
    RALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVE
    PGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPE
    DQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGD
    HPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGA
    APCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRG
    LHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRL
    EFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGES
    PKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGR
    QLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGG
    FSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETL
    DSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGH
    LQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGS
    SPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVV

Product Description

  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 300 μg/mL in PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • AGRN
  • Full Name
  • Agrin
  • Introduction
  • This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • AGRN; CMS8; AGRIN; CMSPPD; agrin proteoglycan; Agrin

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