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Magic™ Membrane Protein Human AXL (AXL receptor tyrosine kinase) Expressed in NS0 for Antibody Discovery, Partial (33-440aa) (CAT#: MPX0348K)

Datasheet
This product is a 71.7 kDa Human AXL membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • AXL
  • Protein Length
  • Partial (33-440aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 71.7 kDa
  • TMD
  • 1
  • Sequence
  • EESPFVGNPGNITGARGL
    TGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVS
    QLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTV
    AANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKT
    SSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLS
    GIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
    PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAF
    VHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVS
    NLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKE

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.1 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • AXL
  • Full Name
  • AXL receptor tyrosine kinase
  • Introduction
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
  • Alternative Names
  • AXL; ARK; UFO; JTK11; Tyro7; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene; AXL receptor tyrosine kinase

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