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Magic™ Membrane Protein Human BACE1 (Beta-secretase 1) Expressed in HEK293 for Antibody Discovery, Partial (22-457aa) (CAT#: MPX0125K)

Datasheet
This product is a 49 kDa Human BACE1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BACE1
  • Protein Length
  • Partial (22-457aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 49 kDa
  • TMD
  • 1
  • Sequence
  • TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMT

Product Description

  • Expression Systems
  • HEK293
  • Protein Format
  • Soluble
  • Endotoxin
  • < 1.0 EU per 1 μg
  • Purity
  • > 95 % SDS-PAGE.
  • Buffer
  • pH: 7.40, Constituents: 95% PBS, 5% Trehalose

Target

  • Target Protein
  • BACE1
  • Full Name
  • Beta-secretase 1
  • Introduction
  • This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
  • Alternative Names
  • BACE1; ASP2; BACE; HSPC104; beta-secretase 1; APP beta-secretase; asp 2; aspartyl protease 2; beta-secretase 1 precursor variant 1; beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme; beta-site amyloid beta A4 precursor protein-cleaving enzyme; memapsin-2; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; Beta-secretase 1

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