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Magic™ Membrane Protein Human BACE2 (Beta-secretase 2) Expressed in NS0 for Antibody Discovery, Partial (29-466aa) (CAT#: MPX0195K)

Datasheet
This product is a 49 kDa Human BACE2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BACE2
  • Protein Length
  • Partial (29-466aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 49 kDa
  • TMD
  • 1
  • Sequence
  • FTLPLRVAAATNRVVAPTPGPG
    TPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
    PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYT
    QGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLA
    YATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLV
    LGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
    IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSET
    PWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISP
    STNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFST
    EDVASNCVPAQSLSEP

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 10xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris and NaCl.

Target

  • Target Protein
  • BACE2
  • Full Name
  • Beta-secretase 2
  • Introduction
  • This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; SLCO3A1/BACE2 fusion; aspartyl protease 1; beta-site APP-cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; Beta-secretase 2

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