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Magic™ Membrane Protein Human CDH5 (Cadherin 5) Expressed in NS0 for Antibody Discovery, Partial (48-593aa) (CAT#: MPX0055K)

Datasheet
This product is a 89 kDa Human CDH5 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CDH5
  • Protein Length
  • Partial (48-593aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 89 kDa
  • TMD
  • 1
  • Sequence
  • DWI
    WNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETG
    DVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPV
    FTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYF
    AIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQD
    INDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG
    DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS
    PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDA
    ARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKEL
    DSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQI
    SAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKV
    HFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQ

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • CDH5
  • Full Name
  • Cadherin 5
  • Introduction
  • This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.
  • Alternative Names
  • 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; CDH5; Cadherin 5

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