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Magic™ Membrane Protein Human DSC2 (Desmocollin 2) Expressed in NS0 for Antibody Discovery, Partial (136-684aa) (CAT#: MPX0482K)

Datasheet
This product is a 62.2 kDa Human DSC2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSC2
  • Protein Length
  • Partial (136-684aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 62.2 kDa
  • TMD
  • 1
  • Sequence
  • RWAPIPCSMLENSLG
    PFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRP
    VDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTF
    TIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPT
    TGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVND
    HLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNE
    NGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPR
    SAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPET
    RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVL
    ASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPD
    EPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPI
    TVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPR

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • DSC2
  • Full Name
  • Desmocollin 2
  • Introduction
  • This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • DSC2; DG2; DSC3; CDHF2; ARVD11; DGII/III; desmocollin-2; cadherin family member 2; desmosomal glycoprotein II/III; Desmocollin 2

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