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Magic™ Membrane Protein Human DSG3 (Desmoglein 3) Expressed in NS0 for Antibody Discovery, Partial (50-615aa) (CAT#: MPX0227K)

Datasheet
This product is a 89.5 kDa Human DSG3 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSG3
  • Protein Length
  • Partial (50-615aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 89.5 kDa
  • TMD
  • 1
  • Sequence
  • E
    WVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIF
    VVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDI
    NDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVS
    QEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQ
    CECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN
    WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVK
    NKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKK
    LVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNM
    NRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKD
    AVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSAL
    LRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP
    TTSPGTRYGRPHSGR

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in MES and NaCl.

Target

  • Target Protein
  • DSG3
  • Full Name
  • Desmoglein 3
  • Introduction
  • This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
  • Alternative Names
  • DSG3; PVA; ABOLM; CDHF6; desmoglein-3; 130 kDa pemphigus vulgaris antigen; cadherin family member 6; Desmoglein 3

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