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Magic™ Membrane Protein Human EPOR (Erythropoietin receptor) Expressed in NS0 for Antibody Discovery, Partial (25-250aa) (CAT#: MPX0298K)

Datasheet
This product is a 51.4 kDa Human EPOR membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • EPOR
  • Protein Length
  • Partial (25-250aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 51.4 kDa
  • TMD
  • 1
  • Sequence
  • APPPNLPDPKFESKAALLAARGPEEL
    LCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTAR
    GAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVG
    LVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILE
    GRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDP

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.

Target

  • Target Protein
  • EPOR
  • Full Name
  • Erythropoietin receptor
  • Introduction
  • This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • EPOR; EPO-R; truncated erythropoietin receptor; Erythropoietin receptor

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