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Magic™ Membrane Protein Human ERBB2 (Erb-b2 receptor tyrosine kinase 2) with His-Flag tag for Antibody Discovery (CAT#: MP0335X)

Datasheet
This product is a 73.5 kDa Human ERBB2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ERBB2
  • Protein Length
  • Full-length
  • Molecular Weight
  • 73.5 kDa
  • TMD
  • 1

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His-Flag
  • Purification
  • Ni affinity column
  • Purity
  • > 90% as determined by SEC-HPLC
  • Buffer
  • 1x PBS, pH7.4 (0.09% NaN3)

Target

  • Target Protein
  • ERBB2
  • Full Name
  • Erb-b2 receptor tyrosine kinase 2
  • Introduction
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized
  • Alternative Names
  • CD340; HER-2; HER-2/neu; HER2; NEU; NGL; TKR1; c-erb B2/neu protein,erbB-2; herstatin,neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

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