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Magic™ Membrane Protein Human ERBB4 (Erb-b2 receptor tyrosine kinase 4) Expressed in NS0 for Antibody Discovery, Partial (26-649aa) (CAT#: MPX0093K)

Datasheet
This product is a 97 kDa Human ERBB4 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ERBB4
  • Protein Length
  • Partial (26-649aa)
  • Protein Class
  • Transporter
  • Molecular Weight
  • 97 kDa
  • TMD
  • 1
  • Sequence
  • QSVCAGTENKLSSLSDLEQQYRALR
    KYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLE
    NLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVD
    QNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGP
    TENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACM
    NFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
    SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDS
    SNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG
    FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
    KEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG
    MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS
    ICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
    NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG2 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • ERBB4
  • Full Name
  • Erb-b2 receptor tyrosine kinase 4
  • Introduction
  • This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Alternative Names
  • ERBB4; HER4; ALS19; p180erbB4; receptor tyrosine-protein kinase erbB-4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; Erb-b2 receptor tyrosine kinase 4

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