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Magic™ Membrane Protein Human F11R (F11 receptor) Expressed in NS0 for Antibody Discovery, Partial (28-242aa) (CAT#: MPX0551K)

Datasheet
This product is a 50 kDa Human F11R membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • F11R
  • Protein Length
  • Partial (28-242aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 50 kDa
  • TMD
  • 1
  • Sequence
  • SVTVHSSEPEVRIPENNPVKLSC
    AYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVT
    REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAV
    LTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD
    PLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAA

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.01 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • F11R
  • Full Name
  • F11 receptor
  • Introduction
  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
  • Alternative Names
  • F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule A; junctional adhesion molecule 1; platelet F11 receptor; platelet adhesion molecule 1; F11 receptor

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