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Magic™ Membrane Protein Human FCAR (Fc fragment of IgA receptor) Expressed in NS0 for Antibody Discovery, Partial (22-227aa) (CAT#: MPX0433K)

Datasheet
This product is a 24.3 kDa Human FCAR membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FCAR
  • Protein Length
  • Partial (22-227aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 24.3 kDa
  • TMD
  • 1
  • Sequence
  • QEGDFPMPFISAKSSPVIPLDGSVKIQCQ
    AIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQC
    QYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAH
    IPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRS
    PYLWSFPSNALELVVTDSIHQDYTTQN

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.01 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • FCAR
  • Full Name
  • Fc fragment of IgA receptor
  • Introduction
  • This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • FCAR; CD89; FcalphaRI; CTB-61M7.2; immunoglobulin alpha Fc receptor; FCAR variant 14; Fc alpha receptor; Fc fragment of IgA, receptor for; Fc fragment of IgA receptor

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