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Magic™ Membrane Protein Human FUT3 (Fucosyltransferase 3 (Lewis blood group)) Expressed in NS0 for Antibody Discovery, Partial (35-361aa) (CAT#: MPX0578K)

Datasheet
This product is a 39 kDa Human FUT3 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FUT3
  • Protein Length
  • Partial (35-361aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 39 kDa
  • TMD
  • 1
  • Sequence
  • RVSRDDATGSPRAPSG
    SSRQDTTPTRPTLLILLWTWPFHIPVALSRCSEMVPGTADCHITADRKVY
    PQADTVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALD
    RYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNW
    KPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENS
    LHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPK
    DLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRY
    QTVRSIAAWFT

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris and NaCl.

Target

  • Target Protein
  • FUT3
  • Full Name
  • Fucosyltransferase 3 (Lewis blood group)
  • Introduction
  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection.
  • Alternative Names
  • FUT3; LE; Les; FT3B; CD174; FucT-III; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; Lewis FT; alpha-(1,3/1,4)-fucosyltransferase; alpha-3-fucosyltransferase FUT3; blood group Lewis alpha-4-fucosyltransferase; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase III; galactoside 3(4)-L-fucosyltransferase; truncated fucosyltransferase 3; Fucosyltransferase 3 (Lewis blood group)

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