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Magic™ Membrane Protein Human GALNT4 (Polypeptide N-acetylgalactosaminyltransferase 4) Expressed in NS0 for Antibody Discovery, Partial (36-578aa) (CAT#: MPX0432K)

Datasheet
This product is a 64 kDa Human GALNT4 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GALNT4
  • Protein Length
  • Partial (36-578aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 64 kDa
  • TMD
  • 1
  • Sequence
  • AGAGRARELGSRRLS
    DLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERY
    AINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWST
    LLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIR
    TNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETA
    VVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISR
    IDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGG
    KLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPP
    ARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRS
    RGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVT
    ELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSA
    YRTPEGRPDVQMRTCDALDKNQIWSFEK

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris and NaCl.

Target

  • Target Protein
  • GALNT4
  • Full Name
  • Polypeptide N-acetylgalactosaminyltransferase 4
  • Introduction
  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.
  • Alternative Names
  • GALNT4; GALNACT4; GALNAC-T4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4); polypeptide GalNAc transferase 4; pp-GaNTase 4; protein-UDP acetylgalactosaminyltransferase 4; Polypeptide N-acetylgalactosaminyltransferase 4

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