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Magic™ Membrane Protein Human GHR (Growth hormone receptor) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (19-264aa) (CAT#: MPX4284K)

Datasheet
This product is a 44.4kDa Human GHR membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GHR
  • Protein Length
  • Partial (19-264aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 44.4kDa
  • TMD
  • 1
  • Sequence
  • FSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFY

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis and SUMO tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris-based buffer, 50% glycerol

Target

  • Target Protein
  • GHR
  • Full Name
  • Growth hormone receptor
  • Introduction
  • This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
  • Alternative Names
  • GHR; GHBP; GHIP; GH receptor; growth hormone binding protein; mutant growth hormone receptor; serum binding protein; somatotropin receptor; truncated growth hormone receptor; Growth hormone receptor

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