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Magic™ Membrane Protein Human HTRA2 (HtrA serine peptidase 2) Expressed in E.coli for Antibody Discovery, Partial (134-458aa) (CAT#: MPX0794K)

Datasheet
This product is a 36 kDa Human HTRA2 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HTRA2
  • Protein Length
  • Partial (134-458aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 36 kDa
  • TMD
  • 1
  • Sequence
  • AVPSPPPASPRSQYNFI
    ADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVV
    ADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSAD
    VRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
    IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNS
    SSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGS
    PAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTL
    YVTPEVTE

Product Description

  • Activity
  • Yes
  • Expression Systems
  • E.coli
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Purity
  • >85%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Supplied as a 0.2 μm filtered solution in HEPES, NaCl, DTT and Glycerol.

Target

  • Target Protein
  • HTRA2
  • Full Name
  • HtrA serine peptidase 2
  • Introduction
  • This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • HTRA2; OMI; MGCA8; PARK13; PRSS25; serine protease HTRA2, mitochondrial; HtrA-like serine protease; Omi stress-regulated endoprotease; epididymis secretory sperm binding protein; high temperature requirement protein A2; protease, serine, 25; serine protease 25; serine proteinase OMI; HtrA serine peptidase 2

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