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Magic™ Membrane Protein Human JAG1 (Jagged canonical Notch ligand 1) Expressed in CHO for Antibody Discovery, Partial (32-1046aa) (CAT#: MPX0485K)

Datasheet
This product is a 137 kDa Human JAG1 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • JAG1
  • Protein Length
  • Partial (32-1046aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 137 kDa
  • TMD
  • 1
  • Sequence
  • SGQFELEILSMQNVNGELQ
    NGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTP
    VIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDS
    IIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFC
    RPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGD
    CRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYC
    GTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGS
    CKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVC
    PPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDIN
    INDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGG
    HCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCK
    CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG
    PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS
    YKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGK
    TCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLP
    NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG
    DNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGH
    SGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPR
    PCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTS
    DSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYI
    ACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNS

Product Description

  • Activity
  • Yes
  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 200 μg/mL in sterile PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS and EDTA.

Target

  • Target Protein
  • JAG1
  • Full Name
  • Jagged canonical Notch ligand 1
  • Introduction
  • The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
  • Alternative Names
  • JAG1; AGS; AHD; AWS; HJ1; AGS1; DCHE; CD339; JAGL1; protein jagged-1; Jagged canonical Notch ligand 1

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