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Magic™ Membrane Protein Human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) Full Length (CAT#: MPC2243K) Made to Order

Datasheet
This product is a 24.4 kDa Human KDELR2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KDELR2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 24.4 kDa
  • TMD
  • 7
  • Sequence
  • MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLD
    LFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVV
    PVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTH
    YLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYIT
    KVLKGKKLSLPA

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • StrepII and Flag tag at the N-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KDELR2
  • Full Name
  • KDEL endoplasmic reticulum protein retention receptor 2
  • Introduction
  • Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Alternative Names
  • KDELR2; ELP1; OI21; ELP-1; ERD2.2; ER lumen protein-retaining receptor 2; (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ERD-2-like protein; ERD2-like protein 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDEL endoplasmic reticulum protein retention receptor 2

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