Magic™ Membrane Protein Human KIR2DS4 (Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4) Expressed in NS0 for Antibody Discovery, Partial (22-245aa) (CAT#: MPX0486K)

Datasheet

This product is a 51.2 kDa Human KIR2DS4 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
KIR2DS4

Protein Length
Partial (22-245aa)

Protein Class
Receptor

Molecular Weight
51.2 kDa

Sequence
QEGVHRKPSFLALPGHLVKSEETVILQCW
SDVMFEHFLLHREGKFNNTLHLIGEHHDGVSKANFSIGPMMPVLAGTYRC
YGSVPHSPYQLSAPSDPLDMVIIGLYEKPSLSAQPGPTVQAGENVTLSCS
SRSSYDMYHLSREGEAHERRLPAVRSINGTFQADFPLGPATHGGTYRCFG
SFRDAPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLH

Product Description

Activity
Yes

Expression Systems
NS0

Tag
hIgG1 Fc tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
KIR2DS4

Full Name
Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4

Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Alternative Names
KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR-2DS4; killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; KIR antigen 2DS4; P58 natural killer cell receptor clones CL-39/CL-17; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer inhibitory receptor 4-1-2; natural killer-associated transcript 8; p50 killer cell activating receptor KAR-K1d; p58 NK receptor CL-39/CL-17; Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4

Gene ID
3809

UniProt ID
P43632

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