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Magic™ Membrane Protein Human LILRB2 (Leukocyte immunoglobulin like receptor B2) Expressed in NS0 for Antibody Discovery, Partial (24-458aa) (CAT#: MPX0489K)

Datasheet
This product is a 73.9 kDa Human LILRB2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LILRB2
  • Protein Length
  • Partial (24-458aa)
  • Protein Class
  • Receptor; Immunity
  • Molecular Weight
  • 73.9 kDa
  • TMD
  • 1
  • Sequence
  • GTIPKPTLWAEPDSVITQGSPVTLSCQ
    GSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQY
    YSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAF
    GGFILCKEGEEEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYD
    LNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGESLTLQCVSDVG
    YDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAH
    NLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQ
    FHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSL
    NSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPAGPEDQPLTPTGSD
    PQSGLGRH

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • LILRB2
  • Full Name
  • Leukocyte immunoglobulin like receptor B2
  • Introduction
  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • LILRB2; ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10; leukocyte immunoglobulin-like receptor subfamily B member 2; CD85 antigen-like family member D; Ig-like transcript 4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10; Leukocyte immunoglobulin like receptor B2

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