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Magic™ Membrane Protein Human MBTPS1 (Membrane bound transcription factor peptidase, site 1) Full Length (CAT#: MPC4009K) Made to Order

This product is a made-to-order Human MBTPS1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MBTPS1
  • Protein Length
  • Full length
  • Protein Class
  • Protease
  • TMD
  • 1
  • Sequence
  • MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSST
    VVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSD
    FEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNET
    RWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQAD
    VLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHG
    TFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
    IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPA
    DQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRG
    SGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASA
    RRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPY
    CSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFS
    YSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
    QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPL
    DWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEE
    EYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDT
    GGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDG
    VVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCL
    DDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
    EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQ
    KLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQ
    TIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTP
    SV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • MBTPS1
  • Full Name
  • Membrane bound transcription factor peptidase, site 1
  • Introduction
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
  • Alternative Names
  • MBTPS1; S1P; PCSK8; SEDKF; SKI-1; membrane-bound transcription factor site-1 protease; endopeptidase S1P; proprotein convertase subtilisin/kexin type 8; site-1 protease; subtilisin/kexin isozyme-1; Membrane bound transcription factor peptidase, site 1

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