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Magic™ Membrane Protein Human NRCAM (Neuronal cell adhesion molecule) Expressed in NS0 for Antibody Discovery, Partial (30-600aa) (CAT#: MPX0099K)

Datasheet
This product is a 90 kDa Human NRCAM membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NRCAM
  • Protein Length
  • Partial (30-600aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 90 kDa
  • TMD
  • 1
  • Sequence
  • LEVPLDPKLLEDLVQPPTITQ
    QSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPG
    TGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKE
    KLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNG
    DLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAA
    NLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTP
    IIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIH
    HTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVP
    IEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL
    AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHED
    IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVK
    QPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in MES and NaCl.

Target

  • Target Protein
  • NRCAM
  • Full Name
  • Neuronal cell adhesion molecule
  • Introduction
  • Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • NRCAM; NgCAM-related cell adhesion molecule; neuronal surface protein Bravo; Neuronal cell adhesion molecule

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