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Magic™ Membrane Protein Human PCDHGC3 (Protocadherin gamma subfamily C, 3) Expressed in CHO for Antibody Discovery, Partial (30-693aa) (CAT#: MPX0512K)

Datasheet
This product is a 73 kDa Human PCDHGC3 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCDHGC3
  • Protein Length
  • Partial (30-693aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 73 kDa
  • TMD
  • 1
  • Sequence
  • STVIHYEIPEEREKGFAVGNV
    VANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREELCGT
    LPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAP
    GTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDSTKYAELVLER
    ALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYR
    ARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLV
    TGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAP
    EITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLT
    SSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDI
    NDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQG
    AETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATN
    ISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADA
    GHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKD
    NGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFY

Product Description

  • Activity
  • Yes
  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 400 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE with silver staining
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • PCDHGC3
  • Full Name
  • Protocadherin gamma subfamily C, 3
  • Introduction
  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
  • Alternative Names
  • PCDHGC3; PC43; PCDH2; PCDH-GAMMA-C3; protocadherin gamma-C3; cadherin-like 2; protocadherin 43; protocadherin-2; Protocadherin gamma subfamily C, 3

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