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Magic™ Membrane Protein Human PCSK7 (Proprotein convertase subtilisin/kexin type 7) Expressed in NS0 for Antibody Discovery, Partial (38-667aa) (CAT#: MPX0721K)

Datasheet
This product is a 79 kDa Human PCSK7 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCSK7
  • Protein Length
  • Partial (38-667aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 79 kDa
  • TMD
  • 1
  • Sequence
  • LAGTGGPDGQGTG
    GPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQ
    PAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKY
    PQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPN
    YSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVA
    YGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
    HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVT
    IGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTE
    GHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWV
    TNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIP
    QSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPS
    GMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
    QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGL
    KIPEEDGYTITPNTLKT

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 10xHis tag between Arg141 and Ser142
  • Protein Format
  • Soluble
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris, NaCl, CaCl2 and Glycerol.

Target

  • Target Protein
  • PCSK7
  • Full Name
  • Proprotein convertase subtilisin/kexin type 7
  • Introduction
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart.
  • Alternative Names
  • PCSK7; LPC; PC7; PC8; SPC7; lymphoma proprotein convertase; prohormone convertase 7; prohormone convertase PC7; proprotein convertase 7; proprotein convertase 8; proprotein convertase PC7; proprotein convertase subtilisin/kexin type 7 precursor variant 2; subtilisin/kexin-like protease PC7; Proprotein convertase subtilisin/kexin type 7

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