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Magic™ Membrane Protein Human PDCD1 (Programmed cell death 1) Expressed in HEK293 for Antibody Discovery, Partial (25-168aa) (CAT#: MPX0745K)

Datasheet
This product is a 19 kDa Human PDCD1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PDCD1
  • Protein Length
  • Partial (25-168aa)
  • Protein Class
  • Immunity
  • Molecular Weight
  • 19 kDa
  • TMD
  • 1
  • Sequence
  • LDSPDRPWNPPTFSPALLVVTEGDNA
    TFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQL
    PNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAE
    VPTAHPSPSPRPAGQFQT

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • 6xHis and Avi tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 200 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

  • Target Protein
  • PDCD1
  • Full Name
  • Programmed cell death 1
  • Introduction
  • Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
  • Alternative Names
  • PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; programmed cell death 1 protein; protein PD-1; systemic lupus erythematosus susceptibility 2; Programmed cell death 1

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