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Magic™ Membrane Protein Human PILRA (Paired immunoglobin like type 2 receptor alpha) Expressed in NS0 for Antibody Discovery, Partial (20-196aa) (CAT#: MPX0789K)

Datasheet
This product is a 20.9 kDa Human PILRA membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PILRA
  • Protein Length
  • Partial (20-196aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 20.9 kDa
  • TMD
  • 1
  • Sequence
  • QPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWE
    LATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQ
    SVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRV
    TQGKRRSDSWHISLET

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS and EDTA.

Target

  • Target Protein
  • PILRA
  • Full Name
  • Paired immunoglobin like type 2 receptor alpha
  • Introduction
  • Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
  • Alternative Names
  • PILRA; FDF03; cell surface receptor FDF03; inhibitory receptor PILR-alpha; Paired immunoglobin like type 2 receptor alpha

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