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Magic™ Membrane Protein Human PSEN1 (Presenilin 1) Full Length (CAT#: MPC1061K) Made to Order

Datasheet
This product is a 53.6 kDa Human PSEN1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PSEN1
  • Protein Length
  • Full length
  • Protein Class
  • Protease
  • Molecular Weight
  • 53.6 kDa
  • TMD
  • 9
  • Sequence
  • MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPL
    SNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI
    KSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILL
    VVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVAL
    LIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLIL
    AVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
    GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGP
    HRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATA
    SGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATD
    YLVQPFMDQLAFHQFYI

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • PSEN1
  • Full Name
  • Presenilin 1
  • Introduction
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
  • Alternative Names
  • PSEN1; AD3; FAD; PS1; PS-1; S182; ACNINV3; presenilin-1; PS1-CTF12; Protein S182; Presenilin 1

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