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Magic™ Membrane Protein Human PTPRS (Protein tyrosine phosphatase receptor type S) Expressed in NS0 for Antibody Discovery, Partial (30-1260aa) (CAT#: MPX0263K)

Datasheet
This product is a 135.8 kDa Human PTPRS membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PTPRS
  • Protein Length
  • Partial (30-1260aa)
  • Protein Class
  • Protein phosphatase
  • Molecular Weight
  • 135.8 kDa
  • TMD
  • 1
  • Sequence
  • EEPPRFIKEPKDQIGVSGGVA
    SFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPR
    DENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTR
    TATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA
    LQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSIL
    PMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
    TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI
    TWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEI
    WVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP
    VEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR
    VLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ
    ESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
    GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGA
    LVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHT
    EVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQH
    GQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQ
    PETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLA
    RWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT
    YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRW
    LPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGL
    KPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV
    LLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLT
    NRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP
    VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR
    QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL
    QKSEPTFAAS

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in HEPES and NaCl.

Target

  • Target Protein
  • PTPRS
  • Full Name
  • Protein tyrosine phosphatase receptor type S
  • Introduction
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
  • Alternative Names
  • PTPRS; R-PTP-S; PTPSIGMA; R-PTP-sigma; receptor-type tyrosine-protein phosphatase S; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; Protein tyrosine phosphatase receptor type S

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