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Magic™ Membrane Protein Human SIGLEC1 (Sialic acid binding Ig like lectin 1) Expressed in NS0 for Antibody Discovery, Partial (20-1641aa) (CAT#: MPX0257K)

Datasheet
This product is a 173.9 kDa Human SIGLEC1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SIGLEC1
  • Protein Length
  • Partial (20-1641aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 173.9 kDa
  • TMD
  • 1
  • Sequence
  • SWGVSSPQDVQGVKGSCLLIPCIFSFPADVE
    VPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNL
    LLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVEL
    LEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE
    TLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGR
    NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA
    GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPN
    EAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER
    SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGH
    ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNA
    TSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA
    LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ
    PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSG
    GGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAST
    SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVL
    WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPK
    LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF
    QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV
    SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAI
    TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL
    GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL
    RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREG
    QLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCG
    VGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP
    AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA
    NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRW
    LQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV
    LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTG
    HVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE
    PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH
    VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG
    ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDI
    EALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQ

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >80%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • SIGLEC1
  • Full Name
  • Sialic acid binding Ig like lectin 1
  • Introduction
  • This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.
  • Alternative Names
  • SIGLEC1; SN; CD169; SIGLEC-1; sialoadhesin; sialic acid binding Ig-like lectin 1, sialoadhesin; sialic acid-binding immunoglobulin-like lectin 1; Sialic acid binding Ig like lectin 1

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