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Magic™ Membrane Protein Human SIGLEC8 (Sialic acid binding Ig like lectin 8) Expressed in NS0 for Antibody Discovery, Partial (17-363aa) (CAT#: MPX0343K)

Datasheet
This product is a 64 kDa Human SIGLEC8 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SIGLEC8
  • Protein Length
  • Partial (17-363aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 64 kDa
  • TMD
  • 1
  • Sequence
  • MEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFS
    YPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLG
    DIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFV
    TALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPG
    PTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNL
    TMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSL
    TLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGT
    GTSRPVSQVTLAA

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

  • Target Protein
  • SIGLEC8
  • Full Name
  • Sialic acid binding Ig like lectin 8
  • Introduction
  • Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490).
  • Alternative Names
  • SIGLEC8; SAF2; SIGLEC-8; SIGLEC8L; sialic acid-binding Ig-like lectin 8; CDw329; SAF-2; sialoadhesin family member 2; Sialic acid binding Ig like lectin 8

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