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Magic™ Membrane Protein Human TMPRSS2 (Transmembrane serine protease 2) Expressed in E.coli with MBP tag at N-terminal, 6xHis and Avi tag at C-terminal for Antibody Discovery, Partial (106-492aa) (CAT#: MPX4082K)

Datasheet
This product is a 90.6 kDa Human TMPRSS2 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TMPRSS2
  • Protein Length
  • Partial (106-492aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 90.6 kDa
  • TMD
  • 1
  • Sequence
  • WKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • MBP tag at N-terminal, 6xHis and Avi tag at C-terminal
  • Protein Format
  • Soluble
  • Purity
  • >85% as determined by SDS-PAGE and HPLC
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • TMPRSS2
  • Full Name
  • Transmembrane serine protease 2
  • Introduction
  • This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • TMPRSS2; PRSS10; transmembrane protease serine 2; epitheliasin; serine protease 10; transmembrane protease, serine 2; Transmembrane serine protease 2

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