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Magic™ Membrane Protein Human WNT3 (Wnt family member 3) for Antibody Discovery (CAT#: MP0064Q)

Datasheet
This product is a 37.4 kDa Human WNT3 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • WNT3
  • Protein Length
  • Full-length
  • Protein Class
  • Druggable Genome, Secreted Protein, Transmembrane
  • Molecular Weight
  • 37.4 kDa
  • Sequence
  • MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVA
    EGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICG
    CDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHG
    LSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENS
    PNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYD
    VHTCK

Product Description

  • Expression Systems
  • CHO
  • Tag
  • C-DDK
  • Purity
  • > 90% as determined by SDS-PAGE and Coomassie blue staining
  • Buffer
  • PBS, pH7.4,10% glycerol

Target

  • Target Protein
  • WNT3
  • Full Name
  • Wnt family member 3
  • Introduction
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
  • Alternative Names
  • INT4; TETAMS; proto-oncogene Wnt-3; WNT-3 proto-oncogene protein; proto-oncogene Int-4 homolog; wingless-type MMTV integration site family, member 3

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