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Magic™ Membrane Protein Mouse Elane (Elastase, neutrophil expressed) for Antibody Discovery (CAT#: MP1570J)

Datasheet
This product is Mouse Elane membrane protein expressed in Yeast, E.coli, In Vivo Biotinylation, Baculovirus, or Mammalian cell. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • Elane
  • Protein Length
  • Partial (27-265aa)
  • Protein Class
  • Drug Target
  • Sequence
  • SEIV GGRPARPHAW PFMASLQRRG GHFCGATLIA RNFVMSAAHC VNGLNFRSVQ VVLGAHDLRR QERTRQTFSV QRIFENGFDP SQLLNDIVII QLNGSATINA NVQVAQLPAQ GQGVGDRTPC LAMGWGRLGT NRPSPSVLQE LNVTVVTNMC RRRVNVCTLV PRRQAGICFG DSGGPLVCNN LVQGIDSFIR GGCGSGLYPD AFAPVAEFAD WINSIIRSHN DHLLTHPKDR EGRTN

Product Description

  • Expression Systems
  • Yeast
    E.coli
    In Vivo Biotinylation in E.coli
    Baculovirus
    Mammalian cell
  • Tag
  • N-His or Tag-Free
  • Reconstitution
  • Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-58% of glycerol (final concentration).
  • Purity
  • >85% as determined by SDS-PAGE
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • Elane
  • Full Name
  • Elastase, neutrophil expressed
  • Introduction
  • This gene encodes a member of the chymotrypsin-like family of serine protease enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lacking the encoded protein exhibit increased susceptibility to sepsis and death following intraperitoneal infection with Gram negative bacteria. This gene is located adjacent to a related proteinase gene on chromosome 10.
  • Alternative Names
  • N; El; NE; Ela2; F430011M15Rik; Elane; Ela2; Neutrophil elastase; EC 3.4.21.37; Elastase-2; Leukocyte elastase

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