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Magic™ Recombinant Human Claudin 18.2 Membrane Protein in Virus-Like Particles (MP-VLPs) (CAT#: MPVLP-001)

Datasheet
This product is recombinant Human Claudin 18.2 in VLPs form. This product is produced from HEK293 by co-expressing the retroviral structural core polyprotein (gag) and the target membrane protein. MP-VLPs display highly-expressed copies of membrane proteins in their native conformation, providing an alternative to membrane protein stable cell lines, membrane preparations, detergent-solubilized proteins and other membrane protein preparation strategies. MP-VLPs can be used for a wide range of applications in antibody production, antibody discovery, antibody characterization, binding assays and functional assays.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Claudin 18.2
  • Protein Length
  • Full length (1-261aa)
  • Protein Class
  • Cell-adhesion; GPCR
  • Molecular Weight
  • 27.8 kDa
  • TMD
  • 4
  • Sequence
  • MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; Antibody Production; Antibody Discovery; Antibody Characterization; Binding Assays; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Tag free
  • Protein Format
  • Membrane Protein-Virus Like Particles (MP-VLPs)
  • Purity
  • >95% as determined by HPLC
  • Buffer
  • Supplied as 0.22um filtered solution in PBS(pH 7.4).

Target

  • Target Protein
  • Claudin 18.2
  • Full Name
  • Claudin 18
  • Introduction
  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • SFTA5; SFTPJ; claudin-18; Claudin 18.2; Claudin18; Claudin-18; CLDN18; DKFZp564B2062; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J

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