Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMelanocortin receptors (MCRs) are members of the rhodopsin-like G protein-coupled receptors family with 7-transmembrane domains. MCRs can be activated by members of the melanocortin derivatives of precursor peptide proopiomelanocortin (POMC), including α-Melanocyte-stimulating hormone (α-MSH), β-MSH, γ-MSH and adrenocorticotrophin (ACTH). These receptors are inhibited by endogenous inverse agonists agouti signaling peptide and agouti-related peptide. There are five known subtypes of MCRs, namely MC1R, MC2R, MC3R, MC4R, MC5R. Different melanocortin receptor presents distinct tissue distributions throughout the nervous system and periphery and distinct selectivity for the various melanocortin peptides. Activation of all five receptors results in adenylate cyclase activity and cAMP production. The multiple physiologic roles of MCRs reveal their irreplaceable status in evolutionary history. MC1R is associated with pigmentation genetics, MC2R in steroidogenesis, and MC5R has an exocrine function especially in sebaceous gland secretion. Abundant in brain, MC3R and MC4R play key roles in energy homeostasis. Mutations in MC4R are the most common cause of autosomal dominant obesity. More recently, fat mass, weight, risk of obesity, and insulin resistance are associated with common variants near the MC4R locus.
Here show five subtypes of MCRs (MC1R to MC5R). The distribution may be a parameter to distinguish different MCRs. MC1R is mainly expressed in melanocytes and preferentially binds α-MSH; MC2R in the adrenal cortex and mainly binds ACTH; MC3R and MC4R in the nervous system, and MC5R in sebaceous glands and other tissues, e.g., the brain, muscles, lung and kidney. Based on MCRs, a lot of synthetic agonists are under clinical development because of the significance in diagnostic test.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
