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Magic™ Membrane Protein Human Claudin 18.2 Full Length (Nanodisc) (CAT#: MP1520F)

This product is recombinant human claudin 18.2 full length protein. The membrane protein is solublized in detergent with high purity, and then reconstituted in nanodisc form. It can be used for a wide range of applications in antibody production, antibody discovery, antibody characterization, binding assays and functional assays.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Claudin 18.2
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • TMD
  • 4

Product Description

  • Application
  • ELISA; Antibody Production; Antibody Discovery; Antibody Characterization; Binding Assays; Functional Assays
  • Protein Format
  • Membrane Protein-Nanodisc
  • Purity
  • >90%

Target

  • Target Protein
  • Claudin 18.2
  • Full Name
  • Claudin 18.2
  • Introduction
  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • SFTA5; SFTPJ; claudin-18; Claudin 18.2; Claudin18; Claudin-18; CLDN18; DKFZp564B2062; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J

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