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Magic™ Membrane Protein Human GPR31 Full Length (Nanodisc) (CAT#: MP1518F)

Datasheet
This product is recombinant human GPR31 full length expressed and purified in insect cell expression systems. The membrane protein is solublized in detergent with high purity, and then reconstituted in nanodisc form. Human GPR31 protein is stable with 12HETE.It can be used for a wide range of applications in antibody production, antibody discovery, antibody characterization, binding assays and functional assays.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GPR31
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • TMD
  • 7

Product Description

  • Application
  • ELISA; Antibody Production; Antibody Discovery; Antibody Characterization; Binding Assays; Functional Assays
  • Expression Systems
  • Insect Expression System
  • Protein Format
  • Membrane Protein-Nanodisc
  • Purity
  • >90%

Target

  • Target Protein
  • GPR31
  • Full Name
  • G protein-coupled receptor 31
  • Introduction
  • This protein shows high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers. 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth. It plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM. It contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1+ phagocytes for the uptake of luminal antigens. Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury
  • Alternative Names
  • 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; GPR31; 12-(S)-HETE receptor; 12-HETER; G-protein coupled receptor 31; GPR31/12-HETER; GPR31; HETER; HETER1

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