Single B Cell Sorting based Native™ Goat Antibody Discovery Service

Native™ Goat Antibody Discovery

Scientists from Creative Biolabs now provide customized antibody discovery services to isolate goat monoclonal antibodies with high specificity and affinity utilizing our proprietary technique platform, the Native™ Antibody Discovery Platform. Through this innovative platform, we can precisely pick desirable antibodies out of a large pool of native antibody candidates from antigen-specific B lymphocytes of the immunized goat.

As one of the oldest domesticated species, goat is a member of the family Bovidae, phylogenetically distant to mammals (i.e. rabbit) and rodent species (i.e. mouse). The total serum volume of an adult goat is about 6-7 times larger than that of rabbits. Also, its serum is far more abundant in immunoglobulins than other small animal individuals, which is nearly 20 mg/mL. A large amount of antiserum can be obtained from a single goat, unlike other small animals, thus effectively eliminating individual variability. Therefore, the goat makes the host of choice for large-scale and low-cost antibody production. Monoclonal goat antibodies are commonly used for diverse academic research and clinical applications. Currently, there are extensive studies taking advantage of monoclonal goat antibodies, which have become an essential tool for immunodiagnostic kits, Host Cell Protein (HCP) Assays, potency assays, etc.

Over the past decade, researchers in Creative Biolabs has been dedicated to antibody discovery and successfully developed a brand new technique platform, Native™ Antibody Discovery. In combination with the antigen-specific B lymphocytes cytometry technology, this platform is capable of creating a comprehensive pool of native antibodies, from which the ones with desired properties can be isolated. It offers a novel strategy to generate a large amount of candidates using native pairs heavy- and light-chains that have gone through in vivo affinity maturation. As a result, goat monoclonal antibodies raised from the Native™ platform can ensure much higher specificity and affinity in contrast to conventional techniques. The major advantages of our Native™ antibody products can be characterized as following:

Native paired heavy- and light-chains
Higher affinity due to in vivo affinity maturation
Higher specificity
Higher in vivo stability
Large quantity production is readily available

So far Creative Biolabs has accomplished over 2000 successful native antibody products from various species, including but not limited to:

We have absolute confidence in generating ideal antibodies that not only best recognize the target but also meet specific custom demands. With our cutting-edge technology, extensive expertise and fully understanding of goat antibody repertoire, Creative Biolabs is the right choice to offer high-quality and cost-effective services of Native™ goat antibody discoveries.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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